Upon his return from serving a ten-year sentence in prison, reformed gang leader, S. Lance Ingram, struggles to adapt to a changed Harlem. Unable to use the technological skills he acquired in jail, Lance is forced to accept a position delivering meals for a local food bank. It is here that he befriends Ms. Maddy, 75, a past beauty with a irreverent and hardened shell to whom he delivers dinners. Through her, Lance finds hope, relearning the joys of life and living despite the outwardly bedeviled society in which they find themselves.

In this tale of sex, violence, race, and rock and roll in 1950s Chicago, "Cadillac Records" follows the exciting but turbulent lives of some of America's musical legends, including Muddy Waters, Leonard Chess, Little Walter, Howlin' Wolf, Etta James and Chuck Berry.